The left-handed Z-DNA double helix is held together by traditional Watson-Crick base pairs, but unlike righthanded B-DNA, which has major and minor grooves between the twists of its sugar-phosphate ...

In a new study, scientists have identified a small molecule candidate drug that triggers the formation of left-handed Z-DNA in cells that in turn activates a highly immunogenic programmed pathway of ...

Supercoiling and looping can transmit mechanical stress along the DNA backbone that can promote the separation of the strands of the double helix at specific distant sites, exposing the DNA bases, ...

Inside human cells, biology has pulled off the ultimate packing job, figuring out how to fit six feet of DNA into a nucleus ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, No. 7 (Feb. 15, 2005), pp. 2471-2475 (5 pages) Assembly of Ig genes in B lineage cells involves two distinct ...

In our bodies, there are trillions of cells. From white blood cells to skin cells, each type has its own specific function which helps us perform tasks and survive. But what makes up these cells and ...

Tiny tweaks in DNA folding can have big effects. A study from Umeå University shows that even the most subtle changes in DNA's shape have an important influence on gene activity and energy production.